PUBLICATIONS

岩崎 克典

Ishikane S, Yamahara K, Sada M, Harada K, Kodama M, Ishibashi-Ueda H, Hayakawa K, Mishima K, Iwasaki K, eta al.:Allogeneic administration of fetal membrane-derived mesenchymal stem cells attenuates acute myocarditis in rats. J Mol Cell Cardiol, 49/5, 753-761,2010

Haraguchi T, Iwasaki K, et al.: Telmisartan, a partial agonist of peroxisome proliferator-activated receptor gamma, improves impairment of spatial memory and hippocampal apoptosis in rats treated with repeated cerebral ischemia. Brain Research, 1353, 125-132,2010

Watanabe T, Iwasaki K, et al: Dynamin 1 depletion and memory deficits in rats treated with A-beta and cerebral ischemia, J.Neurosci.Res. 88/9, 1908-1917,2010

Egashira N, Koushi E, Okuno R, Shirakawa A, Mishima K, Iwasaki K, et al.: Depression-like behavior and reduced plasma testosterone levels in the senescence-accelerated mouse. Behav Brain Res., 209/1, 142-14,2010

Pu F, Kaneko T, Enoki M, Irie K, Okamoto T, Sei Y, Egashira N, Oishi R, Mishima K, Kamimura H, Iwasaki K, Fujiwara M.: Ameliorating effects of Kangen-karyu on neuronal damage in rats subjected to repeated cerebral ischemia. J Nat Med. 64/2, 167-174,2010

Hayakawa K, Nakano T, Irie K, Higuchi S, Fujioka M, Orito K, Iwasaki K, et al.: Inhibition of reactive astrocytes with fluorocitrate retards neurovascular remodeling and recovery after focal cerebral ischemia in mice. J Cereb Blood Flow Metab., 30/4, 871-882,2010

Higuchi S, Irie K, Mishima S, Araki M, Ohji M, Shirakawa A, Akitake Y, Matsuyama K, Mishima K, Mishima K, Iwasaki K, Fujiwara M.: The Cannabinoid 1-Receptor Silent Antagonist O-2050 Attenuates Preference for High-Fat Diet and Activated Astrocytes in Mice., J Pharmacol Sci., 112/3, 369-372,2010

Tajima O, Egashira N, Ohmi Y, Fukue Y, Mishima K, Iwasaki K, Fujiwara M, Sugiura Y, Furukawa K, Furukawa K.: Dysfunction of muscarinic acetylcholine receptors as a substantial basis for progressive neurological deterioration in GM3-only mice., Behav Brain Res, 206/1, 101-108,2010

Sano K, Koushi E, Irie K, Higuchi S, Tsuchihashi R, Kinjo J, Egashira N, Oishi R, Uchida N, Nagai H, Nishimura R, Tanaka H, Morimoto S, Mishima K, Iwasaki K, Fujiwara M.: Delta(9)-tetrahydrocannabinol enhances an increase of plasma corticosterone levels induced by forced swim-stress. :Biol Pharm Bull.32.
2065-2067,2009

Yoshikawa M, Go S, Takasaki K, Kakazu Y, Ohashi M, Nagafuku M, Kabayama K, Sekimoto J, Suzuki S, Takaiwa K, Kimitsuki T, Matsumoto N, Komune S, Kamei D, Saito M, Fujiwara M, Iwasaki K, Inokuchi J.: Mice lacking ganglioside GM3 synthase exhibit complete hearing loss due to selective degeneration of the organ of Corti. Proc Natl Acad Sci U S A,106. 9433-9438,2009

Haraguchi T, Takasaki K, Naito T, Hayakawa K, Katsurabayashi S, Mishima K, Iwasaki K, Fujiwara M.: Cerebroprotective action of telmisartan by inhibition of macrophages/microglia expressing HMGB1 via a peroxisome proliferator-activated receptor gamma-dependent mechanism., Neurosci Lett.,464. 151-155,2009

Pu F, Motohashi K, Kaneko T, Tanaka Y, Manome N, Irie K, Takata J, Egashira N, Oishi R, Okamoto T, Sei Y, Yokozawa T, Mishima K, Iwasaki K, Fujiwara M.: Neuroprotective effects of Kangen-karyu on spatial memory impairment in an 8-arm radial maze and neuronal death in the hippocampal CA1 region induced by repeated cerebral ischemia in rats., J Pharmacol Sci.109. 424-430,2009

Uchida N, Egashira N, Iwasaki K, et al: Nishimura R, Fujiwara M.: Yokukansan inhibits social isolation-induced aggression and methamphetamine-induced hyperlocomotion in rodents, Biol Pharm Bull.,32. 372-375,2009

Egashira N, Mishima K, Iwasaki K et al :New topics in vasopressin receptors and approach to novel drugs: role of the vasopressin receptor in psychological and cognitive functions, J Pharmacol Sci.,109. 44-49,2009

Tajima O, Egashira N, Ohmi Y, Fukue Y, Mishima K, Iwasaki K et al: Reduced motor and sensory functions and emotional response in GM3-only mice: emergence from early stage of life and exacerbation with aging, Brain Res,198. 74-82,2009

Watanabe T, Yamagata N, Takasaki K, Naitou T, Katsurabayashi,S K, Egashira N, Mishima K, Iwasaki K,Fujiwara M: Decreased acetylcholine release is correlated to memory impairment in the Tg2576 transgenic mouse model of Alzheimer’s disease,
Brain Res,16. 222-228,2009

Hayakawa K, Irie K, Sano K, Watanabe T, Higuchi S, Enoki M, Nakano T, Harada K, Ishikane S, Ikeda T, Fujioka M, Orito K, Iwasaki K, et al.: Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high-mobility group box1-inhibiting mechanism., Biol Pharm Bull,32. 1538-1544,2009

Watanabe T, Iwasaki K et al: Spatial memory impairment without apoptosis induced by the combination of beta-amyloid oligomers and cerebral ischemia is related to decreased acetylcholine release in rats., J Pharmacol Sci.,106. 84-91,2008

その他53報(2006年〜2010年掲載)


髙田二郎

加藤詠子、続木 敏、高田二郎ら:皮膚外用剤、特許第4439799号(2010.3.24)

髙田二郎、三島健一、中島学ら:虚血性障害抑制剤,国際公開WO 2009/028707 A1 (2009. 5. 3). 指定国移行米国(2010.2.28)

Takata J, Mishima K, Nakashima M, et al, Inhibitor of ischemic disorders. 米国出願12/675,129 (2010.2.25)

安西和紀、上野恵美、伊古田暢夫、髙田二郎:放射線被ばくによる生体障害の予防または治療用薬剤及びその投与キット、特願2009-076324. (2009.3.26).

髙田二郎,福井亨昌、ファルネソール誘導体およびその製造法、特開2009-73831.(2009. 4. 9)

桑田一夫、木村公則、鎌足雄司、松本友治、中村寛則、髙田二郎、西田教行、片峰茂、片岡泰文、児玉耕太:プリオンタンパク質構造変換抑制剤,特開2009-013126. (2009.1.22).

安西和紀、上野恵美、薬丸晴子、上田順市、明石真言、小林静子、髙田二郎、伊古田暢夫:トコフェロールまたはトコトリエノール類のエステル誘導体を有効成分とする放射線防護剤、特開2008-137942. PCT出願PCT/JP2007/072077、指定国移行US出願12/516722 (2009.6.26)

髙田二郎、赤穂菜美、松永和久、加留部善晴、中島学:皮膚外用剤、特開2008-231077. (2008.10.2).

Kato E, Tsuzuki T, Takata J, et al, Skin preparation comprising a tocopherol derivative for external application. 欧州特許EP1446095 B1. (2008.1.16)

髙田二郎、松永和久、加留部善晴ら:ビタミンKヒドロキノン誘導体を用いる癌治療剤および再発予防剤、特許第4040082号.(2007.11.16).

Kamachi H, Aoki H, Kurata Y, Takata J, Whitening Dermatological Preparations, 国際公開WO 2007/091694 A1 (2007.8.16).特開2007-231013 (2007.9.13)

加藤詠子、小方英二、米田 正、高田二郎、美白用化粧料、特許第3819369号.(2006.9.6)

Kato E, Ogata E, Takata J, et al, Whitening cosmetic composition useful for prevention and elimination of pigmentation comprises tocopherol alkylglycine ester and/or its salt. 韓国特許KR 591630 B1. (2006.6.20)


三島健一

Fujioka M, Hayakawa K, Mishima K, Kunizawa A, Irie K, Higuchi S, Nakano T, Muroi C, Fukushima H, Sugimoto M, Banno F, Kokame K, Miyata T, Fujiwara M, Okuchi K, Nishio K. ADAMTS13 gene deletion aggravates ischemic brain damage: a possible neuroprotective role of ADAMTS13 by ameliorating post-ischemic hypoperfusion. Blood. 115(8):1650-1653.(2010)

Hayakawa K, Nakano T, Irie K, Higuchi S, Fujioka M, Orito K, Iwasaki K, Jin G, Lo EH, Mishima K, Fujiwara M. Inhibition of reactive astrocytes with fluorocitrate retards neurovascular remodeling and recovery after focal cerebral ischemia in mice. J Cereb Blood Flow Metab. 30(4):871-882(2010)

Hazekawa M, Kataoka A, Hayakawa K, Uchimasu T, Furuta R, Irie K, Akitake Y, Yoshida M, Fujioka T, Egashira N, Oishi R, Mishima K, Mishima K, Uchida T, Iwasaki K, Fujiwara M. Neuroprotective Effect of Repeated Treatment with Hericium Erinaceum in Mice Subjected to Middle Cerebral Artery Occlusion. J Health Science, 56(3) 296-303 (2010)

Tsuji M, Mishima K, Harada K, Fujiwara M, Ikeda T. Sex differences in the benefits of rehabilitative training during adolescence following neonatal hypoxia-ischemia in rats. Exp Neurol. 2010 Sep 15. [Epub ahead of print] PubMed PMID: 20833167

Hayakawa K, Irie K, Sano K, Watanabe T, Higuchi S, Enoki M, Nakano T, Harada K, Ishikane S, Ikeda T, Fujioka M, Orito K, Iwasaki K, Mishima K, Fujiwara M. Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high-mobility group box1-inhibiting mechanism. Biol Pharm Bull. 32(9):1538-44 (2009)

Pu F, Motohashi K, Kaneko T, Tanaka Y, Manome N, Irie K, Takata J, Egashira N, Oishi R, Okamoto T, Sei Y, Yokozawa T, Mishima K, Iwasaki K, Fujiwara M. Neuroprotective effects of Kangen-karyu on spatial memory impairment in an 8-arm radial maze and neuronal death in the hippocampal CA1 region induced by repeated cerebral ischemia in rats. J Pharmacol Sci. 109(3):424-340(2009)

Haraguchi T, Takasaki K, Naito T, Hayakawa K, Katsurabayashi S, Mishima K, Iwasaki K, Fujiwara M. Cerebroprotective action of telmisartan by inhibition of macrophages/microglia expressing HMGB1 via a peroxisome proliferator-activated receptor gamma-dependent mechanism. Neurosci Lett. 464(3):151-5 (2009)

Hayakawa K, Mishima K, Irie K, Hazekawa M, Mishima S, Fujioka M, Orito K, Egashira N, Katsurabayashi S, Takasaki K, Iwasaki K, Fujiwara M. Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism. Neuropharmacology. 55(8):1280- 1286(2008)

Hayakawa K, Mishima K, Nozako M, Irie K, Hazekawa M, Mishima S, Fujioka M, Orito K, Egashira N, Iwasaki K, Fujiwara M, Delayed treatment with minocycline improves neurological impairment via activated microglia expressing high-mobility group box1 inhibiting mechanism Stroke 39(3)::951-958 (2008)

Hayakawa K, Mishima K, Hazekawa M, Sano K, Irie K, Orito K, Egawa T, Nishimura R, Egashira N, Iwasaki K, Fujiwara M Cannabidiol potentiates pharmacological effects of Delta-9-tetrahydrocannabinol via CB1 receptor dependent mechanism. Brain Res 1188, 157-4 (2008)

Hayakawa K, Mishima K, Nozako M, Hazekawa M, Irie K, Fujioka M, Orito K, Abe K, Hasebe N, Egashira N, Iwasaki K, Fujiwara M. Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism. J Neurochem. 102, 1488-1496 (2007)

Hayakawa K, Mishima K, Nozako M, Ogata A, Hazekawa M, Liu AX, Fujioka M, Abe K, Hasebe N, Egashira N, Iwasaki K, Fujiwara M. Repeated treatment with cannabidiol but not Delta(9)- tetrahydrocannabinol has a neuroprotective effect without the development of tolerance. Neuropharmacology. 52(4), 1079-1087 (2007)

Hayakawa K, Mishima K, Nozako M, Hazekawa M, Ogata A, Fujioka M, Harada K, Mishima S, Orito K, Egashira N, Iwasaki K, Fujiwara M. Delta(9)-tetrahydrocannabinol (Delta(9)-THC) prevents cerebral infarction via hypothalamic-independent hypothermia. Life Sci. 80, 1466-1471 (2007)

Hayakawa K, Mishima K, Nozako M, Hazekawa M, Aoyama Y, Ogata A, Harada K, Fujioka M, Abe K, Egashira N, Iwasaki K, Fujiwara M. High-cholesterol feeding aggravates cerebral infarction via decreasing the CB(1) receptor. Neurosci Lett. 414:183-187 (2007)

Ikeda T, Mishima K, Aoo N, Harada K, Liu AX, Egashira N, Iwasaki K, Fujiwara M, Ikenoue T. Rehabilitative training tasks improve spatial learning impairment in the water maze following hypoxic-ischemic insult in neonatal rats. Pediatr Res. 59(1):61-65 (2006)

藤原道弘,江頭伸昭,三島健一,ヤマブシタケの脳神経保護効果,FFI Journal 211:141-147(2006)

その他44報(2006年〜2010年掲載)


山内淳史

Dohgu, S., Takata, F., Matsumoto, J., Oda, M., Harada, E., Watanabe, T., Nishioku, T., Shuto, H., Yamauchi, A., Kataoka, Y. Autocrine and paracrine up-regulation of blood-brain barrier function by plasminogen activator inhibitor-1. Microvasc. Res. (in press)

Sumi N, Nishioku T, Takata F, Matsumoto J, Watanabe T, Shuto H, Yamauchi A, Dohgu S, Kataoka Y. Lipopolysaccharide-activated microglia induce dysfunction of the blood-brain barrier in rat microvascular endothelial cells co-cultured with microglia. Cell Mol Neurobiol. 2010, 30(2):247-53.

Nishioku T, Matsumoto J, Dohgu S, Sumi N, Miyao K, Takata F, Shuto H, Yamauchi A, Kataoka Y. Tumor necrosis factor-alpha mediates the blood-brain barrier dysfunction induced by activated microglia in mouse brain microvascular endothelial cells. J Pharmacol Sci. 2010, 112(2):251-4.

Kumagai K, Shirabe S, Miyata N, Murata M, Yamauchi A, Kataoka Y, Niwa M. Sodium pentosan polysulfate resulted in cartilage improvement in knee osteoarthritis–an open clinical trial. BMC Clin Pharmacol. 2010, 10:7.

Dohgu S, Sumi N, Nishioku T, Takata F, Watanabe T, Naito M, Shuto H, Yamauchi A, Kataoka Y. Cyclosporin A induces hyperpermeability of the blood-brain barrier by inhibiting autocrine adrenomedullin-mediated up-regulation of endothelial barrier function. Eur J Pharmacol. 2010, 644(1-3):5-9.

Nishioku T, Yamauchi A, Takata F, Watanabe T, Furusho K, Shuto H, Dohgu S, Kataoka Y. Disruption of the blood-brain barrier in collagen-induced arthritic mice. Neurosci Lett. 2010, 482(3):208-11.

Sejima H, Tominaga K, Egawa T, Ikeda M, Shibuya K, Kameyama N, Yamauchi A, Shuto H, Kataoka Y. Gender differences in tail-skin flushing induced by nitrates and phosphodiesterase type 5 inhibitors in a climacteric mouse model. Eur J Pharmacol. 10;624(1-3):66-70.

Sumi N, Nishioku T, Takata F, Matsumoto J, Watanabe T, Shuto H, Yamauchi A, Dohgu S, Kataoka Y. Lipopolysaccharide-activated microglia induce dysfunction of the blood-brain barrier in rat microvascular endothelial cells co-cultured with microglia. Cell. Mol. Neurobiol. 30(2):247-53.

Takata F, Dohgu S, Nishioku T, Takahashi H, Harada E, Makino I, Nakashima M, Yamauchi A, Kataoka Y. Adrenomedullin-induced relaxation of rat brain pericytes is related to the reduced phosphorylation of myosin light chain through the cAMP/PKA signaling pathway. Neurosci Lett. 2009; 449(1):71-75.

Nishioku T, Dohgu S, Takata F, Eto T, Ishikawa N, Kodama KB, Nakagawa S, Yamauchi A, KataokaY. Detachment of brain pericytes from the basal lamina is involved in disruption of the blood-brain barrier caused by lipopolysaccharide-induced sepsis in mice. Cell Mol Neurobiol. 2009;29(3):309-316.

Takata F, Sumi N, Nishioku T, Harada E, Wakigawa T, Shuto H, Yamauchi A, Kataoka Y. Oncostatin M induces functional and structural impairment of blood-brain barriers comprised of rat brain capillary endothelial cells. Neurosci Lett. 2008;441(2):163-166.

Ikeda M, Egawa T, Yamauchi A, Sohda Y, Koga A, Tominaga K, Shuto H, Kataoka Y. Selective serotonin reuptake inhibitors fluvoxamine and paroxetine restore forced exercise-induced temperature dysregulation in ovariectomized mice. Eur J Pharmacol. 2008;579(1-3):439-444.

Dohgu S, Nishioku T, Sumi N, Takata F, Nakagawa S, Naito M, Tsuruo T, Yamauchi A, Shuto H, Kataoka Y. Adverse effect of cyclosporin A on barrier functions of cerebral microvascular endothelial cells after hypoxia-reoxygenation damage in vitro. Cell Mol Neurobiol. 2007;27(7):889-899.

Takata F, Dohgu S, Yamauchi A, Sumi N, Nakagawa S, Naito M, Tsuruo T, Shuto H, Kataoka Y. Inhibition of transforming growth factor-beta production in brain pericytes contributes to cyclosporin A-induced dysfunction of the blood-brain barrier. Cell Mol Neurobiol. 2007;27(3):317-328.

Yamauchi A, Dohgu S, Nishioku T, Shuto H, Naito M, Tsuruo T, Sawada Y, Kataoka Y. An inhibitory roleof nitric oxide in the dynamic regulation of the blood-brain barrier function. Cell Mol Neurobiol. 2007;27(3):263-270.

Nishioku T, Takata F, Yamauchi A, Sumi N, Yamamoto I, Fujino A, Naito M, Tsuruo T, Shuto H, Kataoka Y. Protective action of indapamide, a thiazide-like diuretic, on ischemia-induced injury and barrier dysfunction in mouse brain microvascular endothelial cells. J Pharmacol Sci. 2007;103(3):323-327.

Hayashi K, Pu H, Andras IE, Eum SY, Yamauchi A, Hennig B, Toborek M. HIV-TAT protein upregulates expression of multidrug resistance protein 1 in the blood-brain barrier. J Cereb Blood Flow Metab. 2006, 26(8):1052-65

Dohgu, S., Takata, F., Matsumoto, J., Oda, M., Harada, E., Watanabe, T., Nishioku, T., Shuto, H., Yamauchi, A., Kataoka, Y. Autocrine and paracrine up-regulation of blood-brain barrier function by plasminogen activator inhibitor-1. Microvasc. Res. (in press)

Nishioku, T., Yamauchi, A., Takata, F., Watanabe, T., Furusho, K., Shuto, H., Dohgu, S., Kataoka, Y. Disruption of the blood-brain barrier in collagen-induced arthritic mice. Neurosci. Lett. 482, 208-211 (2010)


道具伸也

Dohgu, S., Sumi, N., Nishioku, T., Takata, F., Watanabe, T., Naito, M., Shuto, H., Yamauchi, A., Kataoka, Y. Cyclosporin A induces hyperpermeability of the blood-brain barrier by inhibiting autocrine adrenomedullin-mediated up-regulation of endothelial barrier function. Eur. J. Pharmacol. 644, 5-9 (2010)

Nishioku, T., Matsumoto, J., Dohgu, S., Sumi, N., Miyao, K., Takata, F., Shuto, H., Yamauchi, A.,Kataoka,Y. Tumor necrosis factor-alpha mediates the blood-brain barrier dysfunction induced by activated microglia in mouse brain microvascular endothelial cells. J. Pharmacol. Sci.. 112, 251-254 (2010)

Sumi, N., Nishioku, T., Takata, F., Matsumoto, J., Watanabe, T., Shuto, H., Yamauchi, A., Dohgu, S., Kataoka, Y. Lipopolysaccharide-activated microglia induce dysfunction of the blood-brain barrier in rat microvascular endothelial cells co-cultured with microglia. Cell. Mol. Neurobiol.. 30, 247-253 (2010)

Jaeger, L.B., Dohgu, S., Hwang M.C. Farr, S.A., Murphy M.P., Fleegal-DeMotta, M.A., Lynch, J.L., Robinson, S.M., Niehoff, M.L., Johnson S.N., Kumar, V.B., Banks, W.A. Testing the neurovascular hypothesis of Alzheimer’s disease: LRP-1 antisense reduces blood-brain barrier clearance and increases brain levels of amyloid-beta protein and impairs cognition. J Alzheimers Dis. 17, 553-570 (2009)

Jaeger, L.B., Dohgu, S., Sultana, R., Lynch, J.L., Owen, J.B., Erickson, M.A., Shah, G.N., Price, T.O., Fleegal-DeMotta, M.A., Butterfiled, D.A., Banks, W.A. Lipopolysaccharide alters the blood-brain barrier transport of amyloid b protein: A mechanism for inflammation in the progression of Alzheimer’s disease. Brain Behav. Immun. 23, 507-517 (2009)

Nishioku, T., Dohgu, S., Takata, F., Eto, T., Ishikawa, N., Kodama, K.B., Nakagawa, S., Yamauchi, A., Kataoka,Y. Detachment of brain pericytes from the basal lamina is involved in disruption of the blood-brain barrier caused by lipopolysaccharide-induced sepsis in mice. Cell. Mol. Neurobiol. 29, 309-316 (2009)

Fleegal-DeMotta, M.A., Dohgu, S., Banks, W.A. Angiotensin II modulates BBB permeability via activation of the AT1 receptor in brain endothelial cells. J. Cereb. Blood Flow Metab. 29, 640-647 (2009)

Takata, F., Dohgu, S., Nishioku, T., Takahashi, H., Harada, E., Makino, I., Nakashima, M., Yamauchi, A., Kataoka, Y. Adrenomedullin-induced relaxation of rat brain pericytes is related to the reduced phosphorylation of myosin light chain through the cAMP/PKA signaling pathway. Neurosci. Lett. 449, 71-75 (2009)

Dohgu, S., Banks, W.A. Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by the p38 mitogen-activated protein kinase pathway. Exp. Neurol. 210, 740-749 (2008)

Festuccia, W.T., Oztezcan, S., Laplante, M., Berthiaume, M., Michel, C., Dohgu, S., Denis, R.G., Brito, M.N., Brito, N.A., Miller, D.S., Banks, W.A., Bartness, T.J., Richard, D., Deshaies, Y. PPAR--mediated positive energy balance in the rat is associated with reduced sympathetic drive to adipose tissue and thyroid status. Endocrinology 149, 2121-2130 (2008)

Banks, W.A., Dohgu, S., Lynch, J.L., Fleegal-DeMotta, M.A., Erickson, M.A., Nakaoke, R., Vo, T.Q. Nitric oxide isoenzymes reglulate LPS-enhanced insulin transport across the blood-brain barrier. Endocrinology 149, 1514-1523 (2008)

Dohgu, S., Nishioku, T., Sumi, N., Takata, F., Nakagawa, S., Naito, M., Tsuruo, T., Yamauchi, A., Shuto, H., Kataoka, Y. Adverse effect of cyclosporin A on barrier functions of cerebral microvascular endothelial cells after hypoxia-reoxygenation damage in vitro. Cell. Mol. Neurobiol. 27, 889-899 (2007)

Mare, S., Penugonda, S., Robinson, S.M., Dohgu, S., Banks, W.A., Ercal, N.
Copper complexing decreases the ability of amyloid  peptide to cross the BBB and enter brain parenchyma. Peptides. 28, 1424-1432 (2007)

Yamauchi, A., Dohgu, S., Nishioku, T., Shuto, H., Naito, M., Tsuruo, T., Sawada, Y., Kataoka, Y. An inhibitory role of nitric oxide in the dynamic regulation of the blood-brain barrier function. Cell. Mol. Neurobiol. 27, 263-270 (2007)

Takata, F., Dohgu, S., Yamauchi, A., Sumi, N., Nakagawa, S., Naito, M., Tsuruo, T., Shuto, H., Kataoka, Y. Inhibition of transforming growth factor-production in brain pericytes contributes to cyclosporin A-induced dysfunction of the blood-brain barrier. Cell. Mol. Neurobiol. 27, 317-328 (2007)

Verma, S., Nakaoke, R., Dohgu, S., Banks, W.A. Release of cytokines by brain endothelial cells: A polarized response to lipopolysaccharide Brain Behav. Immun. 20, 449-455 (2006)


小山 進

Zhang, R., Sun, L., Hayashi, Y., Liu, X., Koyama, S., Wu, Z., Nakanishi, H. Acute p38-mediated inhibition of NMDA-induced outward currents in hippocampal CA1 neurons by interleukin-1. Neurobiology of Disease 38, 68-77, 2010.

Murata, Y., Kobayashi, D., Imuta, N., Haraguchi, K., Ieiri, I., Nishimura, R., Koyama, S., Mine, K. Effects of the serotonin 1A, 2A, 2C, 3A, and 3B and serotonin transporter gene polymorphisms on the occurrence of paroxetine discontinuation syndrome. Journal of Clinical Psychopharmacology 30, 11-17, 2010.

Zhang, R., Yamada, J., Hayashi, Y., Wu, Z., Koyama, S., Nakanishi, H. Inhibition of NMDA-induced outward currents by interleukin-1 in hippocampal neurons. Biochemical and Biophysical Research Communication 372, 816-820, 2008.

Koyama, S., Akaike, N. Activation of -opioid receptor selectively potentiates NMDA-induced outward currents in rat locus coeruleus neurons. Neuroscience Research 60, 22-28.

Koyama,S., Brodie,M.S., Appel, S.B. Ethanol inhibition of M-current and ethanol-induced direct excitation of ventral tegmental area dopamine neurons. Journal of Neurophysiology 97, 1977-1985, 2007.

Appel, S.B., Wise, L., McDaid, J., Koyama, S., McElvain, M.A. and Brodie, M.S. The effects of long chain length n-alcohols on the firing frequency of dopaminergic neurons of the ventral tegmental area. Journal of Pharmacology and Experimental Therapeutics 318, 1137-1145, 2006.

Koyama, S., Appel, S.B. A-type K+ current of dopamine and GABA neurons in the ventral tegmental area. Journal of Neurophysiology 96, 544-554, 2006.

Koyama, S., Appel, S.B. Characterization of M-current in ventral tegmental area dopamine neurons. Journal of Neurophysiology 96, 535-543, 2006.


坪井義夫

Hirano S, Shinotoh H, Kobayashi T, Tsuboi Y, et al. Brain acetylcholinesterase activity in FTDP-17 studied by PET Neurology(2006, 66(8):1276-1277)

Rainov NG, Tsuboi Y, Krolak-Salmon P, Vighetto A, Doh-Ura K. Experimental treatments for human transmissible spongiform encephalopathies: is there a role for pentosan polysulfate? Expert Opin Biol Ther. (2007; 7:713-726)

Martinez-Martin P, Schapira AH, Stocchi F, Sethi K, Odin P, Macphee G, Brown RG, Naidu Y, Clayton L, Abe K, Tsuboi Y, et al. Prevalence of nonmotor symptoms in Parkinson’s disease in an international setting; Study using nonmotor symptoms questionnaire in 545 patients. Mov Disord. (2007; 22:1623-1629.)

Arvanitakis Z, Witte RJ, Dickson DW, Tsuboi Y, et al. Clinical-pathologic study of biomarkers in FTDP-17 (PPND family with N279K tau mutation). Parkinsonism Relat Disord. (2007; 13:230-239.)

Tsuboi Y, Uchikado H, Dickson DW. Neuropathology of Parkinson’s disease dementia and dementia with Lewy bodies with reference to striatal pathology. Parkinsonism Relat Disord. (2007;13 Suppl 3: S221-S224)

Fujiki F, Tsuboi Y, Hori T, Yamada T. Aseptic meningitis as initial presentation of acute disseminated encephalomyelitis. J Neurol Sci. (2008 ;272:129-131)

Fujishiro H, Tsuboi Y, Lin WL, Uchikado H, Dickson DW. Co-localization of tau and alpha-synuclein in the olfactory bulb in Alzheimer’s disease with amygdala Lewy bodies. Acta Neuropathol. (2008; 116:17-24, First author: the same contribution)

Tsuboi Y, Dickson DW, Nabeshima K, Schmeichel AM, Wszolek ZK, Yamada T, Benarroch EE. Neurodegeneration involving putative respiratory neurons in Perry syndrome. Acta Neuropathol. (2008;115:263-268)

Wider C, Dickson DW, Stoessl AJ, Tsuboi Y, et al. Pallidonigral TDP-43 pathology in Perry syndrome. Parkinsonism Relat Disord. (2009;15:281-286)

Farrer MJ, Hulihan MM, Kachergus JM, Dächsel JC, Stoessl AJ, Grantier LL, Calne S, Calne DB, Lechevalier B, Chapon F, Tsuboi Y, Yamada T, et al. DCTN1 mutations in Perry syndrome. Nat Genet. (2009 ; 41:163-165)

Tsuboi Y, Imamura A, Sugimura M, Nakano S, Shirakawa S, Yamada T. Prevalence of restless legs syndrome in a Japanese elderly population. Parkinsonism Relat Disord. (2009; 15:598-601)

Tsuboi Y, Doh-Ura K, Yamada T. Continuous intraventricular infusion of pentosan polysulfate: clinical trial against prion diseases. Neuropathology. 2009;29:632-636.

Terada T, Tsuboi Y, et al. Less protease-resistant PrP in a patient with sporadic CJD treated with intraventricular pentosan polysulphate. Acta Neurologica Scandinavica, (2010;121:127-130)

Murakami K, Miyake Y, Sasaki S, Tanaka K, Fukushima W, Kiyohara C, Tsuboi Y, et al. Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson’s disease: a case-control study in Japan. Br J Nutr. (2010; 26:1-8.)

Miyake Y, Tsuboi Y, et al. LRRK2 Gly2385Arg polymorphism, cigarette smoking, and risk of sporadic Parkinson’s disease: a case-control study in Japan. J Neurol Sci. (2010;297(1-2):15-18)

Umemoto G, Tsuboi Y, Kitashima A, Furuya H, Kikuta T. Impaired Food Transportation in Parkinson’s Disease Related to Lingual Bradykinesia. Dysphagia. (2010 Aug 29.)

Ohshima S, Tsuboi Y, Yamamoto A, Kawakami M, Farrer MJ, Kira J, Shii H. Autonomic failures in Perry syndrome with DCTN1 mutation. Parkinsonism and Related Disorders (2010;16:612-664.)

Dickson DW, Ahmed Z, Algom AA, Tsuboi Y, Josephs KA. Neuropathology of variants of progressive supranuclear palsy. Curr Opin Neurol. (2010; 23 (4):394-400.)

Wider C, Dachsel JC, Farrer MJ, Dickson DW, Tsuboi Y, Wszolek ZK. Elucidating the genetics and pathology of Perry syndrome. J Neurol Sci. (2010; 289:149-154.)

その他総説・著書 47報(2006〜2010年掲載)


井ノ口仁一

Sato T, Tanaka M, Yamamoto S, Ito E, Inokuchi J.,et al. (2010) Effect of Honeycomb-Patterned Surface Topography on the Function of Mesenteric Adipocytes. J Biomater Sci Polym Ed. 21, 1947-1956※査読有

Koda T., Kijimoto-Ochiai S., Uemura S. and Inokuchi J. Specific expression of Neu2 type B in mouse thymus and the existence of a membranebound form in COS cells. (2009) Biochem. Biophys. Res. Commun. 387,729-735

Chisada S.I., Yoshimura Y., Sakaguchi K., Uemura S., Go S., Ikeda K., Uchima H., Matsunaga N., Ogura K., Tai T., Okino N., Taguchi R., Inokuchi J. and Ito M. (2009)
Zebrafish and mouse alpha2,3-sialyltranserases responsible for synthesizing GM4 ganglioside. J. Biol. Chem. 284, 30534-30546

Uemura S., Yoshida S., Shishido F., and Inokuchi J. (2009) The Cytoplasmic tail of GM3 synthase defines its subcelluar localization, stability, and in vivo activity. Mol. Biol. Cell 20, 3088-3100

Yoshikawa M., Go S., Kabayama K., Iwasaki K. and Inokuchi J. et al. (2009)
Mice lacking ganglioside GM3 synthase exhibit complete hearing loss due to selective degeneration of the organ of Corti. Proc. Natl. Acad. Sci.USA 106, 9483-9488

Tajima O., Iwasaki K.,Inokuchi J., Sugiura Y. and Furukawa K, et al. (2009) Reduced motor and sensory functions and emotional response in GM3-only mice: emergence from early stage of life and exacerbation with aging. Behav. Brain Res. 198,74-82.

Sato T., Nagafuku M., Shimizu K., Taira T., Igarashi Y. and Inokuchi J. (2008) Physiological levels of insulin and IGF-1 synergistically enhance the differentiation of mesenteric adipocytes. Cell Biol. Int. 32,1397-1404

Sato T., Nihei Y., Nagafuku M., Igarashi Y. and Inokuchi J., et al. (2008) Circulating Levels of Ganglioside GM3 in Metabolic Syndrome: A Pilot Study. Obesity Research & Clinical Practice. 2, 231-238

Kabayama K., Sato T., Igarashi Y. and Inokuchi J., et al. (2007) Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance. Proc. Natl. Acad. Sci.USA, 104,13678-13683

Noguchi M., Suzuki T., Kabayama K., Igarashi Y. and Inokuchi J., et al. (2007) GM3 synthase gene is a novel biomarker for histological classification and drug sensitivity against epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Cancer Science 98,1625-1632

Uemura S., Fei Feng, Kume M., Yamada K., Kabayama K., Nishimura S., Igarashi Y. and Inokuchi J. (2007) Cell Growth Arrest by Sialic Acid Clusters in Ganglioside GM3 Mimetic Polymers. Glycobiology 17,568-577

Uemura S., Kihara A., Iwaki S., Inokuchi J. and Igarashi Y. (2007) Regulation of the transport and protein levels of the inositol phosphorylceramide mannosyltransferases Csg1 and Csh1 by the Ca2+ -binding protein Csg2. J. Biol. Chem. 282, 8613-8621

Schneider J.S., Bradbury K.A., Anada Y., Inokuchi J. and Anderson DW. (2006) The synthetic ceramide analog l-PDMP partially protects striatal dopamine levels but does not promote dopamine neuron survival in murine models of parkinsonism. Brain Res. 1099,199-205.

Noguchi M., Kabayama K., Uemura S., Kang BW, Saito M., Igarashi Y. and Inokuchi J. (2006) Endogenously Produced Ganglioside GM3 Endows Etoposide and Doxorubicin Resistance by Up-regulating Bcl-2 Expression in 3LL Lewis Lung Carcinoma Cells. Glycobiology 16,641-650

Uemura S., Kurose T., Suzuki T., Yoshida S., Ito M., Saito M., Igarashi Y. and Inokuchi J. (2006) Substitution of the N-glycan Function in Glycosyltransferases by Specific Amino Acids (SUNGA): ST3Gal-V as a model enzyme. Glycobiology 16, 258-270
Inokuchi J. (2010) Membrane Microdomains and Insulin Resistance.
FEBS letters 584, 1864-1871

その他総説・著書 13報(2006〜2010年掲載)

高脂血症治療剤のスクリーニング方法、出願番号 特願2009-269593(H21/11/27)
発明者:井ノ口仁一、永福正和、速水博孝; 出願人:JST

ヘルパーT細胞の選択的機能制御法、出願番号 特願2008-281890(H20/10/31)
発明者:井ノ口仁一、永福正和、大野勳、奥山香織; 出願人:JST

インスリン抵抗性病態を示す疾患の診断方法、出願番号 特願2006-149328, 発明者:井ノ口仁一; 出願人:JST

METHODS OF CHEMOTHERAPY USING 1-PHENYL-2- DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL、United States Patent Number: 5,041,441, Date Aug. 20, 1991、発明者:Radin, NS &Inokuchi, J. ; 出願人:ミシガン大学
Kimura T, Fukuda T, Sahara N, Yamashita S, Murayama M, Mizoroki T, Yoshiike Y, Lee B, Sotiropoulos I, Maeda S, Takashima A., Aggregation of detergent-insoluble tau is involved in neuronal loss but not in synaptic loss. Biol Chem. 2010 Oct 4. [Epub ahead of print]


高島明彦

Peethumnongsin E, Yang L, Kallhoff-Muñoz V, Hu L, Takashima A, Pautler RG, Zheng H. Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function. J Neurosci. 30(40):13409-18. 2010
Takashima A. Tau Aggregation is a Therapeutic Target for Alzheimer’s Disease. Curr Alzheimer Res. 2010 Aug 2. [Epub ahead of print]
Takashima A. Significance of tau in the development of Alzheimer’s disease. Brain Nerve. 62(7):701-8, 2010
Miyasaka T, Sato S, Tatebayashi Y, Takashima A., Microtubule destruction induces tau liberation and its subsequent phosphorylation. FEBS Lett.584(14):3227-32. 2010
Naito AT, Okada S, Minamino T, Iwanaga K, Liu ML, Sumida T, Nomura S, Sahara N, Mizoroki T, Takashima A, et al. Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury. Circ Res.106(11):1692-702. 2010
Fujimura M, Usuki F, Sawada M, Takashima A. Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. Neurotoxicology.30(6):1000-7, 2009
Fujiwara H, Tabuchi M, Yamaguchi T, Iwasaki K, Furukawa K, Sekiguchi K, Ikarashi Y, Kudo Y, Higuchi M, Saido TC, Maeda S, Takashima A, et al. A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer’s amyloid beta proteins in vitro and in vivo. J Neurochem.109(6):1648-57. 2009

Kitamura N, Araya R, Kudoh M, Kishida H, Kimura T, Murayama M, Takashima A, Sakamaki Y, Hashikawa T, Ito S, Ohtsuki S, Terasaki T, Wess J, Yamada M. Beneficial effects of estrogen in a mouse model of cerebrovascular insufficiency. PLoS One.4(4):e5159. 2009

Takashima, A: Tauopathy and brain aging. Handbook of neurochemistry and molecular neurobiology (Springer, NY)
Takashima, A.: Amyloid , tau, and dementia. J. Alzheimer’s Dis. 17(4):729-36. 2009

Takashima, A.: Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: role of GSK-3beta in adult brain. 2009

Sekimata, A., Sato, K., Sato, K., Takashima, A., et al. O-mannosylation is required for the solubilization of heterologously expressed human -amyloid precursor protein in Saccharomyces cerevisiae. Genes Cells 14(2):205-15, 2009

Sahara, N., Maeda, S., and Takashima, A. Tau oligomerization: a role for tau aggregation intermediates linked to neurodegeneration. Curr. Alzheimer Res. 6:591-598 ,2008

Planel, E., Krishnamurthy, P., Miyasaka, T., Liu, L., Herman, M., Kumar, A., Bretteville, A., Figueroa, H.Y., Yu, Y.H., Whittington, R.A., Davies, P., Takashima, A., et al. Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. J. Neurosci. 28(48):12798-12807 ,2008
Kimura, T., Yamashita, S., Nakao S., Park, J-M., Murayama, M., Mizoroki, T., Yoshiike, Y., Sahara, N., and Takashima, A. GSK-3 beta is required for memory reconsolidation in adult brain. PLoSONE 3(10):e3540 ,2008

Yoshiike, Y., Minai, R., Matsuo, Y., Chen, Y.R., Kimura, T., and Takashima, A. Amyloid oligomer conformation in a group of natively folded proteins. PLoSONE 3(9):e3235 ,2008)

Yoshiike, Y., Kimura, T., Yamashita, S., Furudate, H., Mizoroki, T., Murayama, M., and Takashima, A. GABAA Receptor-mediated acceleration of aging-associated memory decline in APP/PS1 mice and its pharmacological treatment by picrotoxin. PLoSONE 3(8):e3029 ,2008

Takashima A. Hyperphosphorylation of tau is a cause of neuronal degeneration. J. Alzheimers Dis. 14(4):371-375 ,2008

Shimojo, M., Sahara, N., Mizoroki, T., Funamoto, S., Morishima-Kawashima, M., Kudo, T., Takeda, M., Ihara, Y., Ichinose, H., and Takashima, A., Enzymatic characteristics of I213T mutant presenilin-1/γ-secretase in cell models and knock-in mouse brains: FAD-linked mutation impairs γ-site cleavage of APP-CTFβ. J. Biol. Chem. 283:(24) 16488-6496 ,2008

その他総説・著書 26報(2006〜2010年掲載)

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